Aiming at the uncertainty and external disturbance of the longitudinal model of hypersonic vehicles, a nonlinear dynamic inverse controller with sliding mode disturbance observer is designed based on the terminal sliding mode control theory.Firstly, feedback linearization is made to the longitudinal motion model of the aircraft to realize the decoupling of the height and velocity channels.The nonlinear dynamic inverse controller is designed by using the pole configuration method.The model parameter uncertainty and external disturbance are regarded as “equivalent disturbance”.The sliding mode disturbance observer is designed to estimate the equivalent disturbance of the system, and it is fed back to the dynamic inverse controller for compensation.The simulation results show that the controller can track the command signal quickly and stably, has strong robustness in the presence of interference, and can meet the requirements of hypersonic flight control.