Analysis of the Application Progress in Laser-induced Breakdown Spectroscopy：A Review（Invited）

Lianbo GUO; Xuechen NIU; Mengsheng ZHANG; Jiayuan ZHOU; Deng ZHANG; Bin LIU

doi:10.3788/gzxb20235203.0352104

Journals >Acta Photonica Sinica >Volume 52 >Issue 3 >Page 0352104 > Article

Acta Photonica Sinica
Vol. 52, Issue 3, 0352104 (2023)

Analysis of the Application Progress in Laser-induced Breakdown Spectroscopy：A Review（Invited）

Lianbo GUO^1,*, Xuechen NIU¹, Mengsheng ZHANG¹, Jiayuan ZHOU¹..., Deng ZHANG¹ and Bin LIU^2,**|Show fewer author(s)

Author Affiliations

¹Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, China

²School of Hydraulic Engineering, Hunan Polytechnic of Water Resources and Electric Power, Changsha 410131, China

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DOI: 10.3788/gzxb20235203.0352104 Cite this Article

Lianbo GUO, Xuechen NIU, Mengsheng ZHANG, Jiayuan ZHOU, Deng ZHANG, Bin LIU. Analysis of the Application Progress in Laser-induced Breakdown Spectroscopy：A Review（Invited）[J]. Acta Photonica Sinica, 2023, 52(3): 0352104 Copy Citation Text

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Fig. 1. Structural model of bituminous coal^［21］

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Fig. 2. The LIBS experimental setup for Hg flue gas^［20］

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Fig. 3. The LIBS experimental setup

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Fig. 4. Experimental setup for the online composition measurement of molten aluminum^［41］

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Fig. 5. LIBS experimental setup for high temperature^［42］

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Fig. 6. Multi-elemental image in a lymph node^［65］

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Fig. 7. LIBS multi-elemental imaging combined with histopathological analysis^［67］

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Fig. 8. Schematic diagram of water contact angle^［83］

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Fig. 9. Schematic diagram of the experimental setup for discharge-assisted LIBS^［89］

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Types	Samples	Substrate	Methods	Accruacy	References
Ovarian cancer	Blood plasma	A high purity graphite plate	BPNN	Sensitivity=71.4%，specificity=86.5%	［49］
Ovarian cancer	Blood plasma	PVDF substrate	LDA，RF	ACC>79.6%	［50］
Lymphoma	Blood	Filter paper	PCA，LDA，KNN	ACC>99.7%，sensitivity >0.996，specificity >0.997	［52］
Lymphoma	Serum	Filter paper	PCA，LDA，QDA，KNN	AUC = 0.990，sensitivity = 0.970，specificity = 0.956	［51］
Multiple myeloma	Serum	Filter paper	PCA，LDA，QDA，KNN	AUC = 0.986，sensitivity = 0.892，specificity = 0.994	［51］
Blood cancer	Serum	Boric acid substrate	KNN，LDA，RSM-LDA	ACC>94.33%	［53］
Melanoma	Homogenized pellets，tissues	—	PCA，LDA	Tissues：sensitivity=96.7%，specificity=99.7% pellets：sensitivity=96.7%，specificity=99.7%	［54］
Melanoma	Blood，tissue homogenates	PVDF，Cu，Al，Si	LDA，FDA，SVM，GB	ACC=96%	［55］
Melanoma	Blood，tissue homogenates	Paraffin-embedded	ANN，LDA，QDA，PLS-DA	ACC=100%	［56］
Glioma	Fresh glioma samples，border infiltrated tissues	Paraffin-embedded and fresh tissue	SVM，KNN	ACC=95%	［57］
Brain tumor	Brain tumor tissue	Paraffin-embedded	MFS，SNN，ANN，KNN，SVM	ACC=88.62%	［58］
Nasopharyngeal carcinoma	Serum	Boric acid substrate	KNN，ELM，RF	ACC=98.33%，sensitivity=99.02%，specificity =97.75%	［59］
Cervical cancer	Normal tissue，cervical cancer samples	Paraffin-embedded	PCA，SVM	ACC= 94.44%	［60］
Lung cancer	Lung tumor tissue，boundary tissue	Liquid nitrogen	PCA，RF，SVM，BT	ACC=98.9%，sensitivity=99.3%，specificity=98.6%	［61］

Table 1. Literature on LIBS detection of cancer in recent five years

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