By taking the National Ignition Facility (NIF) from the USA and the Laser Mégajoule (LMJ) from the France for examples, this paper analyzes the general layout and general structure engineering features of Inertial Confinement Fusion (ICF) laser facility. NIF is designed with a U-shaped building layout, and it not only can provide an optimum laser experimental equipment configuration but also allow the equipment to attach a second target chamber in future. The bundles of LMJ are arranged in an in-line building. Its layout decreases the optical path-length between the output of each beamline and the focusing system also provides an option for a second target chamber exists. The paper suggests that the general layout of an ICF laser facility should meet the requirements of the physical experimental purposes and should be characterized by operation stability ,good integration and higher maintainability. Furthermore, it should design convenient interfaces for future development. In overall design of the equipment, optical elements are packaged into a optical-mehanical assemblies, and replaceable units (LRUs) are assembled with kinematic mounts. The general structure of ICF design should match the arrangement of the laser beams in structural layout and configuration. Moreover, the structure design can not dispense with the function, stability and cleanliness. The assignments of general structure design should meet the requirements of the installation and localization, integration and debugging, operation and maintenance of the optical components and the physical/optical diagnostic equipment.