Aiming at the design features of the Line Replaceable Module (LRM) in the Integrated Modular Avionics, a method is proposed for the design of a Nand-Flash data storage module with high security, high reliability, and large capacity with ARINC653 compliant partitioning operating system.It has a three-layer structure including flash driver layer, flash management layer and file system layer.The method of emergency key data destruction is used to ensure the high security of the system, and the reliability of the system is guaranteed by adopting bad block management, wear leveling and trusted restoring file system.Read/write test, emergency key data destruction test and reliability test were made to the data storage module at different levels and with different file sizes, and the test results show that the module meets the design requirements and can be applied to the field of avionics requiring high reliability and high security.