Long-period gratings (LPGs) are fabricated in a photonic crystal fiber (PCF) using the symmetric point-by-point CO2 laser irradiation method to explore the sensitivity characterization of PCF–LPG. Numerical simulation is used to guide the investigation. It is found that the refractive index (RI) sensitivity of PCF–LPG depends on the coupled cladding modes as well as the coupled resonance wavelength (RW) of the LPG. Experimental studies show that the longer the RW, the higher the RI sensitivity for the same cladding mode. At similar RWs, the lower the cladding mode, the higher the RI sensitivity of PCF–LPG.