In order to improve the design effect of product anti-counterfeiting packaging, a design method of product anti-counterfeiting packaging based on laser interference lithography was proposed. Multi-beam interference information is controlled by fiber-coupled laser transmission, based on fiber waveguide beam splitting forming technology, integrated processing of beam propagation path, based on beam amplitude, phase and polarization joint modulation method, the anti-counterfeiting state characteristic of product anti-counterfeiting packaging is extracted, and the laser interference lithography model is constructed based on amplitude or phase microstructure diffraction unit array transmission method. Multi-beam laser anti-counterfeiting of four beams, five beams and six beams is realized. The test results show that the lowest tampering rate of the proposed method is 0.05%, the decryption time is short, all about 30 ms, MSE is 0.673%, PSNR is 40.40 dB, and SSIM is 0.975. This method is used to design the product anti-counterfeiting packaging, which improves the laser anti-counterfeiting ability of the product and reduces the tampering rate.