The Oxygen absorption characteristic was analyzed and four hyperspectral sensor models were built with full width at half maximum of 15, 10, 5 and 2.5 nm. Four spectral matching styles and six spectral matching algorithms were proposed. The measured spectrum and referenced spectrum with spectral offset were simulated based on MODTRAN radiative transfer model. The spectral calibrations of hyperspectral sensor with different FWHMs were processed using four spectral matching styles and six spectral matching algorithms. Then the in-flight spectral calibration accuracy was analyzed quantitatively. The results show that the spectral calibration based on correlative coefficient of measured apparent radiance and referenced apparent radiance has the highest accuracy.