In accordance with the national strategy of “ecological protection and high quality development of the Yellow River Basin,” this article discussed the development of the Yellow River Delta. First, regional territorial structure was studied. According to the regional characteristics and the development strategies, the breakthrough point of further development is land-sea coordination. Second, territorial function zoning was conducted to divide the research area into different functional zones for development and protection. The functional zones connect land and sea across the coastline, which is convenient for implementation and management of coordination. Third, with respect to land and sea coordination and interconnected development, this study examined several key issues. (1) Harbor system: Take the ports as nodes to link land transportation and sea shipping, revitalize the area with ports, improve the channel, and expand the hinterland. (2) Fishery: Develop the zonal layout of marine fishery, put forward high efficiency ecological fishery models of sea water and fresh water, and land-sea coordination with a wider scope and meaning. (3) Ecology and environment: Include land-sea integrated ecological protection, land and sea environmental co-governance, as well as coastal protection and disaster risk reduction systems. As an integral part of the overall system of the Yellow River Basin, the development of the Yellow River Delta should not only be linked with basin-wide development, but also adapt to local conditions in order to achieve ecological protection and high-quality sustainable development through land and sea coordination.