Aiming at the cross-coupling effect between pitch and yaw channels due to periodic rolling of guided projectiles, we designed a decoupling control algorithm by using feed-forward compensation method together with the PID controller.A mathematical model of the spin-guided projectile was established, and the transfer functions of pitch and yaw direction were obtained.The degree of coupling was determined by using the relative gain, and feed-forward compensation method was used for decoupling.PID control was used together with feed-forward compensator for the design of a guided projectile decoupling control system.This approach simplified the controller, and decoupled the strong coupling system guided projectile.The numerical simulation analysis shows that the control method has rapid response capability, high command tracking accuracy and robustness characteristics under the strong coupling and parameter perturbations.This method achieves the decoupling control system and can satisfy the system performance requirements.