Twenty eight trace elements in the sediment of Lop Nur in different latitude and longitude were tested by ICP-MS. The results showed that the metal contents in the soil profile followed a growing trend from the surface to the bottom. And the essential element P for living body in each sample was very low, and was the lowest on the surface, while was matched in the other four layers. The results will help to understand the ecosystem evolution of Lop Nur drying up after the sediment deposition.