High-resolution is the trend of infrared imaging technology. In order to implement high-resolution infrared imaging in real-time, a technical scheme based on SOPC technology is proposed. Hardware and software co-design architecture is constructed with the core of CPU Micro Blaze to complete such image processing procedures as non-uniformity correction, image denoising, and histogram equalization enhancement, so as to solve the problem of high-speed processing of large-data images and meet the real-time requirement.Compared with traditional hardware architecture of FPGA+DSP, this technical scheme has lower power consumption and is miniaturized with high reliability and high generality. The designed high-resolution infrared image processing system has the advantages of high definition, high contrast and clear image details.