To overcome the problem of cleanliness in the laser′s internal cavity, a glass cavity design for a Nd: glass slab amplifier was proposed, which uses UV-stop quartz glass for its main structure.The design of the main structure of the glass cavity and the sealing are optimized, and metal-coated surfaces are used to prevent light from escaping.The cleanliness of the stainless steel cavity of the slab amplifier of the SG-II-UP laser and the glass cavity of a 100 slab amplifier were compared; the cleanliness of the glass cavity was found to be 70% better than that of the stainless cavity. Further, advanced system analysis program was used to simulate the designed amplifier, with the pumping ratio of the Nd: glass in the glass cavity being increased by 8.84%.Thus, the glass cavity decreases the production of aerosols and enhances the pumping ratio of the Nd∶glass.