In this paper, a high power of cryogenic Tm(8 at.-%),Ho(1.4 at.-%)∶YLF end-pumped by a fiber-coupled laser diode (LD) with number aperture of 0.3, core diameter of 0.4 mm, and central wavelength of 792 nm at 20 ℃ temperature is reported. The highest continuous-wave (CW) power of 5.2 W at 2.05 μm is achieved under pump power of 14.8 W, corresponding to optical-optical conversion efficiency of 35%, and the slope efficiency is greater than 40%. The threshold power is only about 0.48 W because of the long lifetime, large effective emission cross section, and low reabsorption loss in Tm,Ho∶YLF crystal. Under pumping power of 29.6 W with dual-end pumping configuration, the highest CW power of 10.2 W at 2.051 μm is attained, corresponding to optical-optical conversion efficiency of 33%, and the slope efficiency is greater than 36%.