To verify the influence of optical axis pointing error on optical attitude measurement accuracy and provide a theoretical basis for subsequent real-time equipment to realize attitude measurement, based on the central axis method, the algorithm steps were split, and the influence of optical axis pointing error was traced. It was concluded that the influence of pointing error on attitude processing results could be analyzed from two aspects. At the same time, the direct influence of the intersection algorithm in the model and the indirect influence of the dynamic reference outside the model were deduced and analyzed. Through the combination of simulation calculation and measured data, the conclusion that the pose angle error is no more than 0.1° in typical medium and long-term optical attitude measurement in the pointing error of 200" was obtained. It lays a theoretical foundation for the reliability analysis of the existing attitude measurement and the capability expansion of the subsequent range equipment.