Preparation of chitosan-Epigallocatechin-3-O-gallate nanoparticles and their inhibitory effect on the growth of breast cancer cells

Yingyi Liu; Siyi Hu; Yueshu Feng; Peng Zou; Yue Wang; Pei Qin; Jie Yue; Yaotian Liang; Hui Wang; Liwei Liu

doi:10.1142/s1793545818500189

Journals >Journal of Innovative Optical Health Sciences >Volume 11 >Issue 4 >Page 1850018 > Article

Journal of Innovative Optical Health Sciences
Vol. 11, Issue 4, 1850018 (2018)

Preparation of chitosan-Epigallocatechin-3-O-gallate nanoparticles and their inhibitory effect on the growth of breast cancer cells

Yingyi Liu¹, Siyi Hu², Yueshu Feng³, Peng Zou⁴, Yue Wang⁴, Pei Qin⁴, Jie Yue⁴, Yaotian Liang⁴, Hui Wang⁵, and Liwei Liu^6、*

Author Affiliations

¹Bohai Ship-building Vocational College, Huludao 125000, Liaoning, P. R. China

²CAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, P. R. China

³Jilin Weather Modification O±ce, Changchun 130062, Jilin, P. R. China

⁴School of Science, Changchun University of Science and Technology, Changchun 130022, Jilin, P. R. China

⁵Department of Ultrasound, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin, P. R. China

⁶Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Shenzhen University, Shenzhen 518060, P. R. China

show less

DOI: 10.1142/s1793545818500189 Cite this Article

Yingyi Liu, Siyi Hu, Yueshu Feng, Peng Zou, Yue Wang, Pei Qin, Jie Yue, Yaotian Liang, Hui Wang, Liwei Liu. Preparation of chitosan-Epigallocatechin-3-O-gallate nanoparticles and their inhibitory effect on the growth of breast cancer cells[J]. Journal of Innovative Optical Health Sciences, 2018, 11(4): 1850018 Copy Citation Text

show less

Abstract

In this paper, we prepared the nanoparticle drug carrier system between nanoparticles — chitosan and Epigallocatechin-3-O-gallate (EGCG) for breast cancer cell inhibiting application. For this drug carrier system, chitosan acts as a carrier and EGCG as a drug. Which were systematically characterized and thoroughly evaluated in terms of their inhibition rate and biocompatibility. We also did a cell scratch test and the result indicated that the chitosan-EGCG nanoparticles have inhibitory effect on the growth of breast cancer cells. The inhibition rate could reach up to 21.91%. This work revealed that the modification of nanoparticles paved a way for specific biomedical applications.

Keywords

Epigallocatechin-3-O-gallate inhibits tumor nanoparticles

Download Citation

Save the article for my favorites

Paper Information