To explore the feasibility of fabricating nasal prosthesis with selective laser sintering method, a digital model of nasal prostheses for patients was produced through the integration of structural light scanning and CAD technique. A wax model of nasal prostheses was fabricated with selected sintering method under special manufacturing parameters. The result of accuracy evaluation and clinical try-in showed a satisfying shape of wax model and a comparatively high precision. Then the wax pattern was processed into the definitive nasal prosthesis and a clinically satisfying effect was achieved. Comparing with conventional manual methods, the new fabricating method shortens time and simplifies manufacturing steps. This digital and model-free manufacture provides a new method for the automatic manufacture of maxillofacial prostheses, and has potential for the clinical application in the future.