To correct the nonuniformity of long-wave infrared detectors and suppress the nonlinearity and time drift, a combined nonuniformity correction method based on piece-wise two-point correction method and local constant statistics was proposed. Firstly, on the basis of the modeling of nonuniform noise, a piece-wise two-point correction method is performed as a coarse correction step. Then, abnormal pixels are kicked out with the median absolute deviation method, and the mean image is calculated through multiple frames in an iterative manner. Finally, the mean image is filtered to obtain the correction matrix for the fine correction step. Two laboratory calibration experiments and one outfield experiment are performed with a principle prototype. Experimental results demonstrate that the standard deviation of the blackbody can be decreased from 2.75 to 2.26, and the roughness of the outfield scenes from 1.47×10－2 to 1.03×10－2. The proposed method has the characteristic of low complexity, strong robustness, and high precision, and is able to reduce nonuniformity noise effectively.