Observations of the total columns of carbon monoxide(CO) in Hefei area are performed based on ground-based high resolution Fourier transform infrared spectroscopy, and we continuously collect the near-infrared solar absorption spectra and obtain time series of total column of CO through the atmosphere from September 2015 to July 2016. The observation results show that the column-averaged dry air mole fraction XCO in this area has obvious seasonal variation during the measurement period. Observation result shows that in the measured period XCO in Hefei area has obvious seasonal change. In October 2015 it has a smaller value, and then it gradually increases, in March 2016 it reaches the maximum at the end of July. Then it declines gradually, and gets to the minimum. We also analyze the reason of the XCO seasonal variation. In order to verify the observations based on the near-infrared region, we use MOPITT satellite data and CO total columns retrieved from the mid-infrared spectra collected by the same spectrometer at Hefei site to compare with the simultaneous measurements. The comparison results show that the seasonal variation of MOPITT data is similar to that of ground-based near-infrared observations, and overall MOPITT observations are higher than ground-based FTS observations. The seasonal variation and variation range of column values of CO retrieved from the mid-infrared spectra agree with those from the near-infrared spectra. The correlation coefficients between the daily averaged CO total columns of the ground-based near-infrared observations with those of satellite and mid-infrared observations are 085 and 091, respectively, which shows the high correlation and proves the accuracy of the CO total columns of the ground-based near-infrared observations. It is the first time to observe the total columns of carbon monoxide(CO) in Hefei area by using ground-based high resolution Fourier transform infrared spectroscopy, and compare them with MOPITT satellite data to get precise result. It provides the theoretical basis to understand the time and space distribution and changes of CO in atmospheric and trace source-sink distribution of CO in Hefei area.