In order to analyze the radiation property changing and the validity of calibration for HJ-1A/B CCD cameras, a validation method based on multi-spectral reflectance field targets is developed. Firstly, the in-flight validation method for radiation properties of HJ-1A/B CCD is introduced, and the equivalent radiance of HJ-1A/B CCD was calculated by using satellite-field synchronous measurements data in 2013. Then the radiometric calibration results of HJ-1A/B CCD are validated, and the trend of change of in-flight radiation properties of HJ-1A/B CCD is analyzed. The results show that the radiation properties of HJ-1A/B CCD change ceaselessly, and the attenuation of radiation properties of HJ-1A/B CCD is from 3.7% to 39.6% since launched, in-flight calibration for satellites is important to satisfy requirement of quantitative applications of remote sensing data.