Space debris becomes vital factors threatening the safety of working spacecrafts on orbit. The laser ranging technology will play an important role in precise measuring orbits, accurate cataloging, surveillance and forewarning to space debris. Based on the laser link equation, the analysis of laser echo signal detection from different power lasers with different working frequencies is performed. The 50 W power diode pumped solid-state laser system with 200 Hz repetition rate is applied to observe space debris. Combining with the low dark noise detector, range gate generator with the nanosecond controlling precision and high efficient spectral filter, the measurement to space debris with high success rate are realized. Among the measured targets, the minimum cross section is about 0.5 m2 and the farthest distance is more than 2100 km. The results show that the laser ranging system has good performance while using the high power, high repetition rate laser and verify the feasibility of high repetition rate, low pulse energy laser to observe space debris. The results are helpful for the development and application of space debris laser ranging technology with high repetition rate in the future.