In order to overcome the impact of external disturbance on airborne photoelectric gyro stabilized platform, the control strategy based on Pseudo-derivative Feedback (PDF) was applied to achieve high stability and isolation. First, the basic structure of the PDF control was introduced before it was simplified. The advantages of the simplified PDF control in the control structure and control performance compared with classic PI was analyzed theoretically. Then parameters setting strategy of trial and error method for PDF controller was proposed. Finally, a series of simulation comparison experiments were carried out between PDF controller and PI controller in the anti-torque disturbance, isolation of the angular rate disturbance of the vehicle and the plant variation on the airborne photoelectric gyro stabilized platform. The results showed that the servo system of airborne photoelectric gyro stabilized platform with PDF controller was superior to the system with PI controller in the same closed-loop bandwidth. It has smaller overshoot and shorter rise time and regulating time. It is not sensitive to the model variation, and better than PI on the suppression of torque and the airborne attitude disturbances within gyro noise.