Yiping LI, Yufei ZHANG, Guangzhi SUN, Yunyao YE, Xiaozhou SHEN, Gaohua HAN. PARPi increases radiotherapy sensitivity of esophageal squamous cell carcinoma by inhibiting XRCC1 expression[J]. Journal of Radiation Research and Radiation Processing, 2023, 41(3): 030303
Journals >Journal of Radiation Research and Radiation Processing >Volume 41 >Issue 3 >Page 030303 > Article
- Journal of Radiation Research and Radiation Processing
- Vol. 41, Issue 3, 030303 (2023)
Fig. 1. Expression of XRCC1 in ESCC (SP method, ×200): (a) XRCC1 positive, with cytoplasm and nuclei, yellowish-brown particles; (b) XRCC1 negative expression
Fig. 2. Expression of PARP-1 in ESCC (SP method, ×200): (a) PARP-1 positive, with cytoplasm and nuclei, yellow-brown granules; (b) PARP-1 negative expression
Fig. 3. Curves of viability of ECA109 cell treated with different concentrations of AZD2281 for 24 h and 48 h
Fig. 4. Cell survival curves
Fig. 5. RT-PCR analysis of XRCC1 mRNA expression
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Table 1. Number of colonies formed in each group
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Table 2. Parameters obtained by fitting a single-hit multi-target model
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Table 3. XRCC1mRNA relative expression in ECA109 cells of each group
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