A method of calibrating responsivity nonunmiformity for visible charge coupled devices (CCD) is presented, and the measurement uncertainty for the calibration equipment is evaluated. The expanded uncertainty of responsivity non-unmiformity for visible CCD is 0.46%, and the output diameter of the radiation adjustable uniform light source is 200 mm. The measurement uncertainty of the calibration equipment is verified use CCD, the measurement repeatability of the CCD is 0.003% and 0.005% less than 0.23% of the total uncertainty. The measurement repeatability of calibration equipment is reasonable. The calibration equipment can meet the calibration demand for big area array image device, meanwhile can provides a very useful reference for big area array image device factory and customers.