To improve the wear-resisting property of titanium alloy (Ti6Al4V), an experiment of laser cladding (Ti+Al/Ni)/(Cr2O3+CeO2) on titanium alloy by pulsed Nd:YAG laser had been carried out. The microstructure of the clad layer was investigated, and the microhardness was measured. The friction and wear properties of the clad layer were examined in atmosphere. It was found that the microstructures of the clad layer were dispersive undissolved Cr2O3 particles and orbed liquid-precipitated Cr2O3 distributed in the matrixes consisting of fir-tree crystals and eutectics. And a small amount of TiAl ceramic hardening particles was existed. The hardness of the clad zone increased obviously, the maximum was 1150HV, 3～4 times of the substrate. A white narrow metallurgical bonding zone was formatted at interface between the cladding and the substrate, about 10～20 μm. The friction coefficients of the clad layer in dry sliding wear were ranged from 0.2 to 0.3. And the rate of wearing was 4～5 times lower than that of Ti6Al4V alloy guide samples.