Anti-HepG-2 Cell Properties of Rare Earth Tungstosilicic Polyoxometalates Containing 5-Fluorouracil

LIU Xia; WANG Shuai-shuai; FENG Chang-gen

doi:10.3964/j.issn.1000-0593(2012)12-3309-06

Journals >Spectroscopy and Spectral Analysis >Volume 32 >Issue 12 >Page 3309 > Article

Spectroscopy and Spectral Analysis
Vol. 32, Issue 12, 3309 (2012)

Anti-HepG-2 Cell Properties of Rare Earth Tungstosilicic Polyoxometalates Containing 5-Fluorouracil

LIU Xia^1、*, WANG Shuai-shuai², and FENG Chang-gen²

Author Affiliations

¹College of Science, China Agricultural University, Beijing 100193, China

²School of Mechatronical Engineering, Beijing Institute of Technology, Beijing 100081, China

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DOI: 10.3964/j.issn.1000-0593(2012)12-3309-06 Cite this Article

LIU Xia, WANG Shuai-shuai, FENG Chang-gen. Anti-HepG-2 Cell Properties of Rare Earth Tungstosilicic Polyoxometalates Containing 5-Fluorouracil[J]. Spectroscopy and Spectral Analysis, 2012, 32(12): 3309 Copy Citation Text

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Abstract

Two novel rare earth tungstosilicic polyoxometalate containing 5-fluorouracil, K26(C4H4FN2O2)8Pr(SiW11O39)4·10H2O (FPSW) and K26(C4H4FN2O2)8Sm(SiW11O39)4·9H2O (FSSW), were synthesized and their structure were characterized by using elemental analysis, FTIR spectra, X-ray powder diffraction and TG. The antitumor activity tests of the compounds FPSW and FSSW were carried out by the methyl thiazolyl tetrazolium method in hepatocellular carcinoma cell HepG-2. The results showed that FPSW and FSSW could inhibit the HepG-2 cells in vitro significantly. The EC50 of FPSW and FSSW is 1.94×10-5 and 1.32×10-5 mol·L-1 respectively. The therapeutic index of FPSW and FSSW is 0.76 and 1.58 respectively.

Keywords

5-fluorouracil Hepatocellular carcinoma Polyoxometalate Rare earth

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