• Chinese Journal of Lasers
  • Vol. 49, Issue 5, 0507201 (2022)
Zewen Yang1, Lu Zhang1、*, Ning Lü1, Huijun Wang1, Zhenxi Zhang2, and Li Yuan3
Author Affiliations
  • 1State Key Laboratory for Manufacturing Systems Engineering, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, China
  • 2Key Laboratory of Biomedical Information Engineering of Ministry of Education, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, China
  • 3Clinical Lab, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China
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    DOI: 10.3788/CJL202249.0507201 Cite this Article Set citation alerts
    Zewen Yang, Lu Zhang, Ning Lü, Huijun Wang, Zhenxi Zhang, Li Yuan. Progress of Three-Dimensional, Label-Free Quantitative Imaging of Refractive Index in Biological Samples[J]. Chinese Journal of Lasers, 2022, 49(5): 0507201 Copy Citation Text show less

    Abstract

    Conclusion and Prospect

    The use of the refractive index as an endogenous label in 3D quantitative imaging for label-free biological samples is gaining popularity. However, some of the following improvements still need to be made: 1) a more accurate scattering measurement model should be established to improve the imaging resolution at the theoretical level; 2) there is still a necessity to overcome the limitation of sparse data, develop a more effective refractive index 3D reconstruction inversion algorithm, and improve the reconstruction accuracy and calculation speed; 3) as the refractive index is nonspecific for biological features, in-depth analysis of the refractive index in samples is required. At the application level, this study requires mature equipment to advance clinical procedures. Furthermore, its applications can be expanded to other domains of study, including water environment monitoring, food safety, material characterization, virology, and single-molecule analysis.

    Zewen Yang, Lu Zhang, Ning Lü, Huijun Wang, Zhenxi Zhang, Li Yuan. Progress of Three-Dimensional, Label-Free Quantitative Imaging of Refractive Index in Biological Samples[J]. Chinese Journal of Lasers, 2022, 49(5): 0507201
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