A new compression scheme of interferential multispectral images is proposed based on the analyses of the large aperture static imaging spectrometry. There are two novelties in the scheme. One is that a three-dimension wavelet with special motion compensation is proposed. The other is that a new method of three-dimensional asymmetric zerotree coding (AT-3DSPIHT) is put forward. This AT3DSPIHT can make a longer tree in fewer images,which increases the probability of a coefficient value being zero when moving from root to leaves. Moreover,this method needs lower memory and shorter time delay than 3DSPIHT. Experimental results show that the scheme provides a better protection of the spectrum curve and a better performance on the compression.