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    Journals >Chinese Journal of Lasers >Volume 48 >Issue 15 >Page 1507003 > Article
    • Chinese Journal of Lasers
    • Vol. 48, Issue 15, 1507003 (2021)
    Advances on in vivo High-Spatial-Resolution Neural Manipulation Based on Optogenetics
    Lingjie Kong1、2、*, Cheng Jin1, and Guofan Jin1
    Author Affiliations
  • 1State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instrument, Tsinghua University, Beijing 100084, China
  • 2IDG/Mc Govern Institute for Brain Research at Tsinghua, Beijing 100084, China
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    DOI: 10.3788/CJL202148.1507003 Cite this Article Set citation alerts
    Lingjie Kong, Cheng Jin, Guofan Jin. Advances on in vivo High-Spatial-Resolution Neural Manipulation Based on Optogenetics[J]. Chinese Journal of Lasers, 2021, 48(15): 1507003 Copy Citation Text show less
    Serial excitation with spiral scanning[41]. (a) Principle diagram; (b) optical path
    Fig. 1. Serial excitation with spiral scanning[41]. (a) Principle diagram; (b) optical path
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    Serial excitation with extended pattern. (a) Principle diagram; (b) optical path
    Fig. 2. Serial excitation with extended pattern. (a) Principle diagram; (b) optical path
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    Pattern generation methods based on parallel excitation. (a) Schematic of parallel scanning excitation; (b) optical path for intensity modulation; (c) optical path of GPC; (d) optical path of CGH
    Fig. 3. Pattern generation methods based on parallel excitation. (a) Schematic of parallel scanning excitation; (b) optical path for intensity modulation; (c) optical path of GPC; (d) optical path of CGH
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    Block diagrams of CGH algorithms. (a) GS algorithm; (b) NOVO algorithm; (c) DeepCGH algorithm
    Fig. 4. Block diagrams of CGH algorithms. (a) GS algorithm; (b) NOVO algorithm; (c) DeepCGH algorithm
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    TechniqueCore componentAdvantageDisadvantage
    Serial excitation with spiral scanning[9-11]Galvanometric mirrorSingle cell accuracy and high power efficiencyLow time resolution andonly being compatiblewith slow turn-off opsins
    Serial excitation with extended pattern[12]Galvanometric mirror andgratingSingle cell accuracy andhigh power efficiencyLow time resolution
    Parallel illumination by GPC based phase modulation [45]SLM and PCFHigh time resolution, high pattern uniformity , matching targetmorphology, and single cell accuracy (with temporal focusing)Low power efficiencyand power subdividedamong targets
    Multi-foci generation based on CGH withspiral scanning[56]SLM and galvanometric mirrorSingle cell accuracy and high powerefficiencyOnly being compatiblewith slow turn-off opsins
    Parallel illumination with extended patterngenerated by CGH[59-60] SLMHigh time resolution, matching target morphology, and single cell accuracy(with temporal focusing)Power subdivided amongtargets and low patternuniformity
    Table 1. Comparison among in vivo high-spatial-resolution neural manipulation techniques
    Abstract
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    Lingjie Kong, Cheng Jin, Guofan Jin. Advances on in vivo High-Spatial-Resolution Neural Manipulation Based on Optogenetics[J]. Chinese Journal of Lasers, 2021, 48(15): 1507003
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    Paper Information
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