Analysis is made to the damage evolution of the key component of hypersonic aircraft wing and the influence of flight dynamics on the damage.Based on establishment of damage dynamic model of the key components of hypersonic aircraft wing and dynamic model of hypersonic aircraft,and the loading stress analysis of the key components of wing,the effects of flight altitude,air speed,angle of attack and deflection of control surfaces on the dynamic damage characteristics of the key components of wing are studied respectively,thus to confirm the key aircraft variables having significant influence on the damage.The results show that the angle of attack has the most significant influence on the damage evolution of the key components of wing.From the safety and life extending perspectives,the angle of attack should be kept within a strict range while the aircraft is flying at hypersonic speed.The results can provide a valuable reference for the design of structure reliability.