Study on the degradation characteristics and pathway of torasemide in water via electron beam irradiation

Zhibo ZHANG; Haiyang SHAO; Lei CHEN; Chengkai MAO; Yingfei REN; Gang XU

doi:10.11889/j.1000-3436.2022-0042

Journals >Journal of Radiation Research and Radiation Processing >Volume 40 >Issue 5 >Page 050201 > Article

Journal of Radiation Research and Radiation Processing
Vol. 40, Issue 5, 050201 (2022)

Study on the degradation characteristics and pathway of torasemide in water via electron beam irradiation

Zhibo ZHANG, Haiyang SHAO^*, Lei CHEN, Chengkai MAO..., Yingfei REN and Gang XU|Show fewer author(s)

Author Affiliations

School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China

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DOI: 10.11889/j.1000-3436.2022-0042 Cite this Article

Zhibo ZHANG, Haiyang SHAO, Lei CHEN, Chengkai MAO, Yingfei REN, Gang XU. Study on the degradation characteristics and pathway of torasemide in water via electron beam irradiation[J]. Journal of Radiation Research and Radiation Processing, 2022, 40(5): 050201 Copy Citation Text

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Fig. 1. Degradation of torasemide as a function of absorbed dose at different initial concentrations

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Fig. 2. Degradation of torasemide with various radical scavengers

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Fig. 3. Effect of solution pH on torasemide degradation by electron beam irradiation

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Fig. 4. Effect of H₂O₂on torasemide degradation by electron beam irradiation

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Fig. 5. Effects of

C O_{3}^{2 -} (a)

N O_{2}^{-} (b), S O_{3}^{2 -} (c), a n d S O_{4}^{2 -} (d)

on torasemide degradation by electron beam irradiation

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Fig. 6. Proposed pathways of torasemide degradation during EB irradiation

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初始浓度 / (μmol⋅L^-1)	k_d / kGy^-1	D_0.5所需剂量 / kGy	D_0.9所需剂量 / kGy	R²
Initial concentration	Dose constant	Doses required to D_0.5	Doses required to D_0.9
100	4.239	0.164	0.543	0.999 8
150	2.744	0.253	0.839	1.000 0
250	1.466	0.473	1.571	0.997 4
300	1.220	0.568	1.887	0.998 9

Table 1. The dose constant k_d, D_0.5, D_0.9 and the correlation coefficients R² at different initial concentrations of torasemide

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转化产物 Transformation products	分子式 Molecular formula	质荷比 Exact monoisotopic mass of [M+H]⁺	保留时间 / min Retention time	误差 / (mg∙L^-1) Mass error
托拉塞米 Torasemide	C₁₆H₂₀N₄O₃S	349.132 9	9.83	0.3
TP102	C₄H₁₀N₂O	103.086 6	3.55	1.1
TP173	C₅H₇N₃O₂S	174.032 2	2.97	1.3
TP258	C₉H₁₄N₄O₃S	259.085 9	3.11	0.2
TP263	C₁₂H₁₃N₃O₂S	264.080 1	4.45	1.8
TP279	C₁₂H₁₃N₃O₃S	280.075 0	4.98	1.3
TP306	C₁₃H₁₄N₄O₃S	307.085 9	4.46	1.5
TP322	C₁₃H₁₄N₄O₄S	323.080 9	3.68	2.0
TP362	C₁₆H₁₈N₄O₄S	363.112 2	5.30	3.4
TP364	C₁₆H₂₀N₄O₄S	365.127 8	5.30	-4.4

Table 2. Torasemide and its main transformation products of produced during EB irradiation.

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