The Infrared Focal Plane Arrays (IRFPA) imaging system is the main technique tendency of infrared imaging,but the inherent nonuniformity of IRFPA limits its imaging quality crucially.Therefore,real-time nonuniformity correction for IRFPA is the base of the infrared thermo-image system.A non-linear curve fitting correction method for IRFPA with real-time realization is proposed using Altera’s NIOSII embedded software CPU.By creating custom instructions for NIOSII embedded processor,time-consuming algorithm is solved in FPGA.As a result,the parallelism of Field Programmable Gate Array (FPGA) and the flexibility of DSP are combined perfectly,and the performance of the system is improved greatly.The block diagram of hardware circuit and the work processes are introduced.The experimental results show that the system has a large dynamic range and utilizes only one FPGA chip.It is possible to minimize the system.