The use of aluminum alloy high-voltage wire harnesses instead of copper wire harnesses can reduce the weight of electric vehicles, increase battery endurance, and reduce cost. Aiming at the difficulty of reliable and effective connection between aluminum alloy high-voltage wire harness and copper alloy terminal, this paper proposes to use electromagnetic pulse crimping technology (EMPC) to connect aluminum alloy high-voltage wire harness and copper alloy terminal. A set of EMPC device suitable for the connection has been developed. The EMPW device has a maximum discharge energy of 28 kJ. During the crimping process, with the increase of the discharge voltage, the temperature of the terminal surface increases. The aluminum alloy high-voltage wire harness and the copper alloy terminal can be connected reliably at 12 kV. An optical microscope was used to analyze the microstructure of the connection interface, and the electrical and mechanical properties of the interface were tested. The analysis shows that the electromagnetic pulse crimping technology can realize metallurgical combination between the aluminum alloy high-voltage wire harness and the terminal as well as the aluminum alloy core wires. The connection interface has a corrugated morphology and a vortex morphology. The test results show that the contact resistance, vibration test and tensile load test of the joint meet the industrial standards of automobile and the national standards of cable joint.