Xun WU, Ruifeng LIU, Qiuning ZHANG, Xiaohu WANG. Radiobiology and treatment plan progress of FLASH radiotherapy[J]. Journal of Radiation Research and Radiation Processing, 2023, 41(2): 020101
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Fig. 1. (a) Cell survival curves after irradiation at different dose rates; (b) cell survival curves after irradiation at ultra-high dose rates with different oxygen concentrations[9-10]
Dose distribution of spot-reduced plans were equal or better than those of the intensity-modulated proton therapy (IMPT) plans. Organs at risk (OARs) dose distribution in arc-shoot-through plans were sometimes better compared to the other techniques, but integral dose was high
van
Marlen[54]
点峰值剂量率
Spot peak dose rate(SPDR)
“穿透”计划
Transmission/
shoot-through
plan
肺
Lung
FLASH治疗计划的内靶区和计划靶体积剂量与容积调强放疗治疗计划相当,危及器官的剂量更低
FLASH plans had internal target volume (ITV) and planning target volume (PTV) doses comparable withvolumetric modulated arc therapy (VMAT) plans, but achieved lower doses for most OARs
van
Marlen[58]
点峰值剂量率;剂量平均剂量率
SPDR; DADR
“穿透”计划
Transmission/shoot-through plan
头颈部
Head-and-neck
常规分割质子FLASH治疗计划的危及器官剂量与调强质子放疗计划相似,并优于容积调强放疗
Conventionally-fractionated proton FLASH plans achieved comparable OARs-sparing to IMPT and better than VMAT
Wei[59]
平均剂量率
Averaged dose rate(ADR)
“穿透”计划
Transmission/shoot-through plan
肝
Liver
与常规调强质子放疗计划相比,“穿透”计划的剂量学较差
The transmission plans generally yielded inferior dosimetry quality to the conventional IMPT plans
Wei[60]
剂量平均剂量率;剂量阈值剂量率;平均剂量率
DADR; dose threshold dose rate; ADR
布拉格峰计划;“穿透”计划
Bragg peak plans; transmission/shoot-through plan
肺
Lung
相比“穿透”计划,布拉格峰计划能进一步降低危及器官剂量
Compared with the transmission plans, the Bragg peak plans further reduced doses to OARs
Gao[61]
剂量平均剂量率
DADR
布拉格峰计划;“穿透”计划
Bragg peak plans; transmission/shoot-through plan
前列腺、肺、头颈部、脑
Prostate, lung, head-and-neck, brain
“穿透”计划的正常组织保护作用不如布拉格峰计划
Shoot-through plan is generally suboptimal to Bragg peak plans for normal tissue sparing
van
Marlen[62]
剂量平均剂量率
DADR
“穿透”计划
Transmission/shoot-through plan
肺
Lung
FLASH“穿透”计划的剂量分布与VMAT相似,但不如IMPT
FLASH shoot-through plan dosimetry was similar to that of VMAT, but inferior to that of IMPT
Table 2. Proton FLASH radiotherapy treatment plan research
Xun WU, Ruifeng LIU, Qiuning ZHANG, Xiaohu WANG. Radiobiology and treatment plan progress of FLASH radiotherapy[J]. Journal of Radiation Research and Radiation Processing, 2023, 41(2): 020101