Ni-Based alloy coatings with different contends of rare-earth La2O3 are prepared on the surface of 6063 aluminum alloy by using laser cladding. The effects of rare earth La2O3 on microstructure, phase structure and composition of laser cladding Ni-Based alloy coatings on 6063 Al alloys are investigated by means of optical microscope (OM), X-ray diffractometer (XRD), scanning electron microscope (SEM) and energy dispersive spectrometer (EDS). The results show that with increasing the amount of La2O3 (above 5%)，the cladding layer tends to form gas-holes. When the amount of La2O3 is in the range of 0%~2% the same below, the cladding layer tends to form cracks, and coating can′t bind tightly with the matrix. Gas-holes and cracks in the coatings reduced with the addition of 5% La2O3. The main phase structures of Ni-based alloy coatings with different contends of rare-earth La2O3 are β-NiAl (Cr) and a small amount of Al3Ni, AlNi3, Al, etc. After adding rare earth, a little of rare earth compounds La2O3、Al4La is found in XRD diagrams, and NiAl phase (100) crystallographic orientation peak almost disappeared, grain orientation towards (110), (200) and (211), and (110) crystallographic orientation peaks appear different degrees of migration; Compared with Ni60 cladding layer without adding rare earth, Ni60 cladding layer with 5% of rare-earth La2O3 has a uniform element distribution, a lower dilution rate, which significantly reduce the porosity and refine the grain size; The cladding layer mainly composed of NiAl-Cr eutectic structure, rare earth elements segregate at the grain boundary and form some stable rare earth compound such as Al4La.