In this study, 10% (mass fraction) acrylic resin (Paraloid B67, Paraloid B72), fluorocarbon resin (FEVE) and silicone material (WD-10) were used to seal the glaze surface of Qianling green glaze Tang tri-color replica. The color difference, hydrophobicity, ultraviolet (UV) aging resistance, salt spray aging resistance and acid corrosion resistance of different sealing materials were compared and studied by chromaticity meter, video optical contact angle tester, ultraviolet-visible spectrophotometer, infrared spectrometer and super depth of field microscope, and their application scenarios were analyzed. The results show that Paraloid B67 exhibits good color difference and hydrophobicity in the early stage of UV aging, but its performance decreases significantly with the extension of UV aging time, and its acid corrosion resistance and salt spray aging resistance are general, which is suitable for the sealing of indoor glazed pottery cultural relics in humid climate. Paraloid B72 is similar to Paraloid B67 in UV aging performance, but its acid corrosion resistance and salt spray aging resistance are the best, which is suitable for indoor glazed pottery cultural relics protection in complex environments. FEVE performs poorly in acid corrosion resistance and salt spray aging resistance, but the color difference and hydrophobicity change range before and after ultraviolet aging are the smallest, and the anti-ultraviolet aging performance is the best, which is suitable for outdoor glazed pottery cultural relics in areas with stable climate and environment. WD-10 is difficult to form a film on the glaze surface of the replica, which is not suitable for the sealing of glazed pottery relics.