Researches on the laser deposition repair of GH4169 nickel-based superalloy with defects of through-groove damage were conducted. The reasons of occurring defects such as gas porosities and ill bonding in the repaired zone were analyzed. And flawless samples were obtained through optimizing laser process parameters. The microstructure characteristic and mechanical properties of laser deposition repair component were investigated, and the local heat treatment of the laser deposition repair component was done. The results indicate that there is a dense metallurgical bond between the repaired zone and the substrate with the optimized process parameters. The tensile strength of laser deposition repair component can be significantly improved with the local heat treatment.