During the laser cladding process, the traditional methods of microstructure adjustment are to change the laser processing parameters, such as laser power, scanning speed and the size of laser beam. However, these methods only change the boundary of heat transfer of laser cladding layer, the regulation effect is limited. In order to achieve the directional control of heat and mass transfer behavior in laser cladding layer and regulate the shape, the size and the direction of the solidification microstructure effectively, one method using the synergistic effect of electric-magnetic field is proposed. This method can induce the Lorenz force, whose direction, magnitude and frequency are controllable. As a means of volume force, the controllable Lorenz force can drive or drag the convection of the molten pool, which affects the solidification process and realizes the adjustment of microstructure. In this research, the higher influence degree of electric-magnetic synergistic effect is verified numerically and experimentally. The application of this method can improve the fatigue life of the high temperature resistance of turbine parts and decrease the internal defects in the solidification microstructure. Meanwhile, this method can be not only applied in laser cladding process, but also used in laser remelting, laser alloying and laser welding process.