The daily monitoring of the human heart rate and respiratory signals is helpful for the healthy human life management. A non-contact physiological signal monitoring system is designed in this paper. A new chair structure with polyvinylidene fluoride(PVDF) piezoelectric film sensor senses the tiny pressure generated by human vibration, and transmits the vibration signals to the host computer software; then the cardiac shock signal and the breathing signal from the vibration signal are extracted; and display the waveform change is displayed through LabVIEW, thus the real-time monitoring of heart rate and breathing can be carried out. The results show that the heart rate value monitored by the device has an average error of 2.013% and an average respiratory rate error of 4.88% compared with that of the pulse oximeter, which has better practicability.