To meet the requirements of the micro-miniature air-to-air missile and solve the problem of not reaching full field angle, this paper presents a micro-miniature infrared seeker with roll-pitch structure, applying the integration philosophy of optical-mechanical structure and pitching shaft. Compared with the classic roll-pitch frame, this new structure combines two individual pitch shafts; additionally, the optical-mechanical structureusesonly one mechanical part, thus greatly reducing its size. Moreover, this new structure has a focus function that could improve the image quality. After structure design, we conducted thermo-mechanical coupling analysis on structure parts and lens under eight extreme conditions. The results show that the optical-mechanical structure meets the requirement of micro-miniature(80 mm), shock resistance (10g), and high low temperature test (-40℃~60℃). The simulated analysis can predict real conditions and has great guiding significance for optical-mechanical structure design.