The infrared imaging windows of the hyper/supersonic optical dome are encountering severe aero-optical effects (AOEs), so a flow control device, the ramp vortex generator array (RVGA) is proposed based on the ramp vortex generator to inhibit the supersonic mixing layers’ AOE, which is done by the nanotracer-based planar laser scattering technique and ray-tracing method. The experiments prove that under different pressure conditions, RVGA can reduce the mean and standard deviation of the root mean square of the optical path difference (OPDrms) and reduce the supersonic mixing layers’ thickness and mixture a great deal. The AOE of the pressure-matched mixing layer is the weakest. Higher RVGA results in better optical performance. RVGA has the potential to be applied to supersonic film cooling to reduce aero-optical aberrations.