The Infrared Focal Plane Arrays (IRFPA) imaging system is the main technique tendency of infrared imaging,but the inherent nonuniformity of IRFPA crucially limits its imaging quality.Because the operands and data volume are so vast that it is difficult to realize real-time processing in the Non-uniformity Correction (NUC) on the infrared focal plane.In the drop-in handware system,TMS320C6000 DSP was applied to resolve this problem,which combined Linearity and Second-degree Polynomial segment algorithms.The hardware design and implementation flow of the system was described and the experiment results were given.The results show the real-time non-uniformity correction system meets the real-time and high-precision requirements completely.