Periclase-magnesium-aluminate spinel bricks were fabricated by solid-state sintering method using sintered magnesia, fused magnesia-aluminate spinel and magnesium-aluminate spinel hollow spheres with different particle sizes as raw materials. The phase composition of samples was examined by X-ray diffractometer (XRD), the microstructure of samples was characterized by scanning electron microscopy (SEM), and the bulk density and apparent porosity of samples were measured according to the Archimedes principle method. The effects of lightweight magnesia content and sintering temperature on the properties of periclase-magnesium-aluminate spinel bricks were investigated. The results show that with the increase of lightweight magnesia content, the apparent porosity of periclase-magnesium-aluminate spinel bricks increases, and the bulk density has little change, so it has good mechanical properties. When the lightweight magnesia mass fraction is 25%, the maximum flexural strength of periclase-magnesium-aluminate spinel bricks is 9.56 MPa, and the lowest thermal conductivity is 1.92 W·m-1·K-1. The microstructure shows that the aggregate and matrix are well combined and formed microporous channels. Periclase-magnesium-aluminate spinel bricks have good mechanical properties and alkali corrosion resistance because of their unique microporous structure, which further protect samples from alkali corrosion.