In order to improve the screening efficiency and in distribute medical resources rationally,a screening system of cervical pre-cancers based on the opto-electrical joint detection was developed.A hand-held detector with photoelectrodes on top stimulates the cervical tissue with electrical impulses,red light,green light and near-infrared light sequentially.The stimulation responses to opto-electircal stimulation were detected and calculated for the characteristic properties of tissue,which includes the voltage attenuation constant and relative reflectance.These two parameters were applied to classification algorithm to distinguish the cervical pre-cancers from the nornal tissue.313 clinical examples being covered,a clinical database of photoelectricity responses was established by comparying with the histopathological examinations.The results of tissue classification indicates the advantages of electro-optical combination in sensitivity,specificity and total coincidence rate over the separate electrical or optical detection.The total coincidence rate of this system with histopathological examinations achieves 85.1%.For the application,this system has the potential in enhancing the diagnosis rates of cervical pre-cancers with accuracy and portability,especially in underdeveloped areas.