• Journal of Radiation Research and Radiation Processing
  • Vol. 41, Issue 5, 050301 (2023)
Yanhui LI, Xin WU, Tan WANG, Baiyan WANG..., Han ZHANG, Tingyuan NIU, Yuqi NIU and Jianfeng GAO*|Show fewer author(s)
Author Affiliations
  • College of Medicine, Henan University of Chinese Medicine, Zhengzhou 450046, China
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    DOI: 10.11889/j.1000-3436.2023-0004 Cite this Article
    Yanhui LI, Xin WU, Tan WANG, Baiyan WANG, Han ZHANG, Tingyuan NIU, Yuqi NIU, Jianfeng GAO. Effects of different courses of electrotherapy on learning, memory, and Notch signaling in a mouse model of radiation-induced brain injury[J]. Journal of Radiation Research and Radiation Processing, 2023, 41(5): 050301 Copy Citation Text show less
    Effects of different courses of electricity on the morphology of neurons in the hippocampus DG region of mice (×200 times, scale 100 μm); note: K-blank group; M-model group; 1 Week-electroacupuncture group 1; 2 Week-electroacupuncture group 2; 3 Week-electroacupuncture group 3; 4 Week-electroacupuncture group 4; red arrow-cell shrinkage; blue arrow-intercellular space (color online)
    Fig. 1. Effects of different courses of electricity on the morphology of neurons in the hippocampus DG region of mice (×200 times, scale 100 μm); note: K-blank group; M-model group; 1 Week-electroacupuncture group 1; 2 Week-electroacupuncture group 2; 3 Week-electroacupuncture group 3; 4 Week-electroacupuncture group 4; red arrow-cell shrinkage; blue arrow-intercellular space (color online)
    Effects of different courses of electrotherapy on synaptic structure in the DG region of mice hippocampus (× 30 000 times, scale 500 nm); note: red arrow: synaptic vesicles, blue arrow: PSD (color online)
    Fig. 2. Effects of different courses of electrotherapy on synaptic structure in the DG region of mice hippocampus (× 30 000 times, scale 500 nm); note: red arrow: synaptic vesicles, blue arrow: PSD (color online)
    Effects of different courses of electrotherapy on the expression of Notch 1, Hes 1, and ASCL 1 proteins in the DG region of the hippocampus of mice
    Fig. 3. Effects of different courses of electrotherapy on the expression of Notch 1, Hes 1, and ASCL 1 proteins in the DG region of the hippocampus of mice
    组别 Group交替反应得分 Alternate response score
    空白组 Blank group0.93±0.06
    模型组 Model group0.33±0.05##
    电针组1 Electroacupuncture group 10.42±0.11*
    电针组2 Electroacupuncture group 20.60±0.06**
    电针组3 Electroacupuncture group 30.66±0.06**
    电针组4 Electroacupuncture group 40.73±0.05**
    Table 1. Effects of electroacupuncture intervention on learning and memory ability of mice with radiation-induced brain injury

    组别

    Groups

    突触界面率

    Synaptic interface rate

    PSD厚度 / nm

    PSD thickness

    突触间隙 / nm

    Synaptic cleft

    空白组Blank group1.21±0.0274.01±1.7815.61±0.61
    模型组Model group0.98±0.01##38.83±3.70##33.05±3.03##
    电针组 1 Electroacupuncture group 11.09±0.01**43.08±2.3430.53±1.05
    电针组 2 Electroacupuncture group 21.11±0.01**52.13±2.22**27.16±0.92**
    电针组 3 Electroacupuncture group 31.13±0.13**60.70±2.48**21.20±1.67**
    电针组 4 Electroacupuncture group 41.19±0.02**68.38±2.90**17.50±1.80**
    Table 2. Effects of different courses of electrotherapy on synaptic structure of hippocampal DG region of mice
    组别GroupsNotch 1/β-actinHes 1/β-actinASCL 1/β-actin
    空白组Blank group0.38±0.120.65±0.391.66±0.43
    模型组Model group1.02±0.39#1.60±0.26##0.69±0.47#
    电针组 1 Electroacupuncture group 10.76±0.271.23±0.181.08±0.25
    电针组 2 Electroacupuncture group 20.61±0.22*1.03±0.25*1.21±0.36
    电针组 3 Electroacupuncture group 30.39±0.11**0.74±0.31**1.53±0.21*
    电针组 4 Electroacupuncture group 40.39±0.11**0.67±0.24**1.66±0.31**
    Table 3. Different courses of electricity in mice hippocampal DG Notch1, Hes1, ASCL1 protein expression level of influence
    Yanhui LI, Xin WU, Tan WANG, Baiyan WANG, Han ZHANG, Tingyuan NIU, Yuqi NIU, Jianfeng GAO. Effects of different courses of electrotherapy on learning, memory, and Notch signaling in a mouse model of radiation-induced brain injury[J]. Journal of Radiation Research and Radiation Processing, 2023, 41(5): 050301
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