Developing the region into an international innovation and technology hub is the most common, the most advantageous, and the most challenging strategic direction for the Guangdong-Hong Kong-Macao Greater Bay Area in the new era. There is an urgent need for the theoretical research and developing studies of the international innovation and technology hubs. Classical theories of the innovation systems focus more on the interior of innovation systems, paying attention to innovation elements and organization of innovation activities in a single space, but neglect the inextricable link between global and local elements and organizations, lacking comprehensive observations combining macro and micro perspectives. Therefore, on the basis of summarizing the classic innovation system theories, this paper constructs a theoretical model with global vision for the Guangdong-Hong Kong-Macao Greater Bay Area constituting international innovation and technology hubs: "Science and technology" and "talent" are the cores, and "science and technology-industry-global production network" and "talent-environment-world city network" are two chains. Focusing on science and technology and the pooling of talents, it is needed to gather elements of innovative resources, enhance regional innovation capabilities, drive industrial transformation and upgrading, and improve urban functions and environments, so as to reshape the role in the global production network and the world city network. It is considered that the international innovation and technology hubs are the core nodes of the triple networks: global innovation network, global production network and world city network. To develop into an international science and technology innovation center, it is necessary to upgrade its strength and position in the three networks at the same time. Compared with the existing innovation system theories, the new model attaches importance to the internal and external relations with both global and local visions, in which the chain structure avoids the simple listing of elements, but emphasizes the mechanisms of the innovation system. Under this theoretical framework, the double-cores (talent & science and technology) and double-chains (science and technology-industry-global production network & talent-environment-world city network) of the Guangdong-Hong Kong-Macao Greater Bay Area are analyzed, and the paths for the Guangdong-Hong Kong-Macao Greater Bay Area developing into an international technological innovation center are proposed. This paper provides an explanatory tool for the organizing similarities and differences between international innovation and technology hubs under the background of globalization, which is a supplement to the theories of innovation systems.