The hydrophilic surfaces of PA2200 three-dimensional (3D) printing parts are prepared quickly through 248 nm KrF excimer laser irradiation, whose contact angles decrease from 121° to 70° and phase structures do not change after irradiation. With the calibration tools of X-ray diffractometer, Raman spectroscopy, scanning electron microscope, X-ray photoelectron spectroscopy and so on, the surface morphologies and microstructures of printing parts, number and types of polar functional groups are analyzed. The Cassie-Baxter model is also studied. The experimental results show that KrF excimer laser irradiation can not only make PA2200 3D printing part surfaces smooth, but also simultaneously generate C=O double hydrophilic groups, and thus the surface wettability of PA2200 3D printing parts are improved and controlled.