The experiment of laser cladding deposition is conducted via the addition of modifier B to TC4 powder. The induction heating is introduced during the deposition process, and the microstructure change of the TC4 cladding layers under different process conditions is investigated. The results show that, when the modifier B and the induction heating both take roles, the obtained grains are fine, the distribution is uniform, there are no obvious β columnar crystals, and the microstructure shows a typical basket-weave one. When the induction heating temperature is 900 ℃ and the mass fraction of B is 0.1%, 0.05% and 0.025%, respectively, the microstructures are composed of a large amount of lamellar α phases and a small amount of primary α phases, the grain length is 11-18 μm and the width is 4.40-6.90 μm.