• Advanced Photonics
  • Vol. 6, Issue 5, 056003 (2024)
Che-Yung Shen1,2,3, Jingxi Li1,2,3, Yuhang Li1,2,3, Tianyi Gan1,3..., Langxing Bai4, Mona Jarrahi1,3 and Aydogan Ozcan1,2,3,*|Show fewer author(s)
Author Affiliations
  • 1University of California, Los Angeles, Electrical and Computer Engineering Department, Los Angeles, California, United States
  • 2University of California, Los Angeles, Bioengineering Department, Los Angeles, California, United States
  • 3University of California, Los Angeles, California NanoSystems Institute, Los Angeles, California, United States
  • 4University of California, Los Angeles, Department of Computer Science, Los Angeles, California, United States
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    DOI: 10.1117/1.AP.6.5.056003 Cite this Article Set citation alerts
    Che-Yung Shen, Jingxi Li, Yuhang Li, Tianyi Gan, Langxing Bai, Mona Jarrahi, Aydogan Ozcan, "Multiplane quantitative phase imaging using a wavelength-multiplexed diffractive optical processor," Adv. Photon. 6, 056003 (2024) Copy Citation Text show less

    Abstract

    Quantitative phase imaging (QPI) is a label-free technique that provides optical path length information for transparent specimens, finding utility in biology, materials science, and engineering. Here, we present QPI of a three-dimensional (3D) stack of phase-only objects using a wavelength-multiplexed diffractive optical processor. Utilizing multiple spatially engineered diffractive layers trained through deep learning, this diffractive processor can transform the phase distributions of multiple two-dimensional objects at various axial positions into intensity patterns, each encoded at a unique wavelength channel. These wavelength-multiplexed patterns are projected onto a single field of view at the output plane of the diffractive processor, enabling the capture of quantitative phase distributions of input objects located at different axial planes using an intensity-only image sensor. Based on numerical simulations, we show that our diffractive processor could simultaneously achieve all-optical QPI across several distinct axial planes at the input by scanning the illumination wavelength. A proof-of-concept experiment with a 3D-fabricated diffractive processor further validates our approach, showcasing successful imaging of two distinct phase objects at different axial positions by scanning the illumination wavelength in the terahertz spectrum. Diffractive network-based multiplane QPI designs can open up new avenues for compact on-chip phase imaging and sensing devices.
    Dw=|ow|2.

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    Refw=1N(Rw)(x,y)RwDw(x,y),

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    Φw=DwRefw.

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    ΦwΦw(GT)=Ψw(λw),

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    φtr,w=2πλw(no(λw)1)HtrλM,

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    αtr,w=2λw(no(λw)1)HtrλM.

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    t(xq,yq,zl;λ)=exp(2πκhqlλ)exp(j2π(nnair)hqlλ).

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    h=hlearnable+hbase,

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    uql+1(x,y,zl+1;λ)=t(x,y,zl+1;λ)F1{F{uql(x,y,zl+1;λ)}Hql(fx,fy,dm;λ)}.

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    Hql(fx,fy,d;λ)={exp{j2πdλ1(λfx)2(λfy)2}fx2+fy2<1λ20,fx2+fy21λ2

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    t(x,y,zw;λ)=ejΨw(x,y;λ).

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    Lw=1Nx(D)1Ny(D)x=1Nx(D)y=1Ny(D)|Φw(GT)(x,y)Φw(x,y)|2.

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    LQPI=1Mλ=1MαwLw,

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    αwmax(0.1×(LwLmean)+αw,0).

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    L=LQPI+βEffLEff,

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    LEff=ηthreshmin(η,ηthresh),

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    η=(x,y)S|o(x,y)|2(x,y)S|i(x,y)|2.

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    PCC=(Φw(x,y)Φw¯)(Φw(GT)(x,y)Φw(GT)¯)(Φw(x,y)Φw¯)2(Φw(GT)(x,y)Φw(GT)¯)2.

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    MAEPhase=1Nx(D)Ny(D)αtestπx=1Nx(D)y=1Ny(D)|Φw(GT)(x,y)Φw(x,y)|,

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    Che-Yung Shen, Jingxi Li, Yuhang Li, Tianyi Gan, Langxing Bai, Mona Jarrahi, Aydogan Ozcan, "Multiplane quantitative phase imaging using a wavelength-multiplexed diffractive optical processor," Adv. Photon. 6, 056003 (2024)
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