2D-IR correlation spectroscopy was used to do the research on crude and prepared drug of radix scutellariae and the extracts of them.The results show that the holistic shape of peaks among them are similar in the FTIR spectra. In second derivative spectra, the two absorption peaks: 1 745 and 1 411 cm-1 of processed products move to the bigger wavenumber direction, while 1 357 cm-1 of processed products moves to the smaller wavenumber direction; There are conspicuous differences in Two-dimensional infrared correlation spectroscopy among them: Four characteristic peaks are shown between 1 300 and 1 800 cm-1. The intensity of peak at 1 575 cm-1 is the strongest. There are three main districts about the autopeaks of sliced scutellariae. Wine-fried scutellariae has two auto-peak districts, in which all the auto-peaks are positively correlated. The FTIR spectra of total glycoside extract of different samples present characteristic peaks at 1 615, 1 585, 1 450 cm-1(vibration of phenyl framework) and 1 658 cm-1(CO)respectively, therefore, the authors speculated that their mutual component is the compound of phenolic glycoside. The two-dimensional infrared correlation spectra present five automatic peaks (vibration of phenyl framework) in 800-1 800 cm-1(1 366, 1 420, 1 508, 1 585, 1 669 cm-1). So the authors can conclude that a lot of information can be provided by macro-fingerprint technology of infrared spectroscopy which can evaluate overall quality of radix scutellariae accurately and be used to study the characteristics of relevance of crude and prepared scutellariae.