High-energy proton beam sources produced by ultra-intense laser acceleration have wide application prospects in basic physics, materials science, biomedical research and other fields. Based on SILEX-II device of Laser Fusion Research Center, the experimental studies on proton acceleration of nanobrush targets driven by high-contrast femtosecond PW laser pulse have been carried out. Plasma mirror technology was used to further improve the laser contrast, which effectively reduces the influence of pre-pulse on the structure of the nanobrush target. Compared with planar target, the proton cut-off energy of nanobrush targets increased to 1.5 times, and the proton beam yield increased by nearly one order of magnitude. This successfully verifies the enhancement of nanobrush targets on laser ion acceleration at ultra-high power density, and the improved uniformity of the proton beam spatial distribution. These results provide a technical way for the generation and application of high-quality proton beam sources.